UnivTrevesV1, Main, Exploration, bibRecord, 002334

Sex differences in endocrine and psychological responses to psychosocial stress in healthy elderly subjects and the impact of a 2-week dehydroepiandrosterone treatment

Identifieur interne : 002334 ( Main/Exploration ); précédent : 002333; suivant : 002335

Sex differences in endocrine and psychological responses to psychosocial stress in healthy elderly subjects and the impact of a 2-week dehydroepiandrosterone treatment

Auteurs : B. M. Kudielka [Allemagne] ; J. Hellhammer [Allemagne] ; D. H. Hellhammer [Allemagne] ; O. T. Wolf [Allemagne] ; K.-M. Pirke [Allemagne] ; E. Varadi [Hongrie] ; J. Pilz [Allemagne] ; C. Kirschbaum [Allemagne]

Source :

The Journal of clinical endocrinology and metabolism [ 0021-972X ] ; 1998.

RBID : Pascal:98-0276698

Descripteurs français

Pascal (Inist)
- Comportement, Effet psychologique, Stress, Système hypothalamohypophysosurrénalien, Déhydroépiandrostérone, Chimiothérapie, Traitement, Sexe, Hormonodépendance, Age, Etude comparative, Vieillard, Mâle, Femelle.

English descriptors

KwdEn :
- Adrenocorticotropic Hormone (blood), Age, Aged, Behavior, Chemotherapy, Comparative study, Dehydroepiandrosterone, Elderly, Epinephrine (blood), Female, Heart Rate, Hormonodependence, Humans, Hydrocortisone (blood), Hydrocortisone (metabolism), Hypothalamohypophysoadrenal axis, Kinetics, Male, Norepinephrine (blood), Psychological effect, Saliva (metabolism), Sex, Sex Characteristics, Stress, Stress, Physiological (physiopathology), Treatment.
MESH :
- chemical , blood : Adrenocorticotropic Hormone, Epinephrine, Hydrocortisone, Norepinephrine.
- chemical , metabolism : Hydrocortisone.
- metabolism : Saliva.
- physiopathology : Stress, Physiological.
- Aged, Dehydroepiandrosterone, Female, Heart Rate, Humans, Kinetics, Male, Sex Characteristics.

Abstract

Evidence from animal as well as human studies has suggested that significant sex differences exist in hypothalamus-pituitary-adrenal axis (HPA) activity. As gonadal steroids could be important modulators of HPA sex differences, stress responses were investigated in subjects of advanced age after dehydroepiandrosterone (DHEA) or placebo treatment. After a 2-week treatment with 50 mg DHEA daily or placebo, 75 men and women (mean age, 67.6 yr) were exposed to the Trier Social Stress Test (TSST). The TSST is a brief psychosocial stress that consists of a free speech and mental arithmetic task in front of an audience. The results show that the TSST induced significant increases in ACTH, salivary free cortisol, total plasma cortisol, norepinephrine, and heart rates (all P < 0.0001) as well as decreased positive affect in the elderly (P = 0.0009). Men showed larger stress responses in ACTH (P = 0.004), salivary free cortisol (P = 0.044), and plasma total cortisol (P = 0.076) compared to women. No sex differences were observed in norepinephrine, epinephrine, or heart rate responses. In contrast to ACTH and cortisol response differences, women reported that they were significantly more stressed by the TSST than men (P = 0.0051). Women treated with DHEA showed ACTH stress responses similar to those of men, but significantly enhanced compared to those of women taking placebos (P < 0.009). No other stress response differences emerged between DHEA and placebo groups. Finally, DHEA treatment did not result in an improvement of subjective well-being. We conclude that elderly men show larger HPA responses than women to psychosocial stress, as studied in the TSST. Estrogen effects on hypothalamic CRF-producing neurons might be responsible for these sex differences.

Affiliations:

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenocorticotropic Hormone (blood)</term>
<term>Age</term>
<term>Aged</term>
<term>Behavior</term>
<term>Chemotherapy</term>
<term>Comparative study</term>
<term>Dehydroepiandrosterone</term>
<term>Elderly</term>
<term>Epinephrine (blood)</term>
<term>Female</term>
<term>Heart Rate</term>
<term>Hormonodependence</term>
<term>Humans</term>
<term>Hydrocortisone (blood)</term>
<term>Hydrocortisone (metabolism)</term>
<term>Hypothalamohypophysoadrenal axis</term>
<term>Kinetics</term>
<term>Male</term>
<term>Norepinephrine (blood)</term>
<term>Psychological effect</term>
<term>Saliva (metabolism)</term>
<term>Sex</term>
<term>Sex Characteristics</term>
<term>Stress</term>
<term>Stress, Physiological (physiopathology)</term>
<term>Treatment</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Adrenocorticotropic Hormone</term>
<term>Epinephrine</term>
<term>Hydrocortisone</term>
<term>Norepinephrine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Hydrocortisone</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Saliva</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Stress, Physiological</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Dehydroepiandrosterone</term>
<term>Female</term>
<term>Heart Rate</term>
<term>Humans</term>
<term>Kinetics</term>
<term>Male</term>
<term>Sex Characteristics</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Comportement</term>
<term>Effet psychologique</term>
<term>Stress</term>
<term>Système hypothalamohypophysosurrénalien</term>
<term>Déhydroépiandrostérone</term>
<term>Chimiothérapie</term>
<term>Traitement</term>
<term>Sexe</term>
<term>Hormonodépendance</term>
<term>Age</term>
<term>Etude comparative</term>
<term>Vieillard</term>
<term>Mâle</term>
<term>Femelle</term>
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<front><div type="abstract" xml:lang="en">Evidence from animal as well as human studies has suggested that significant sex differences exist in hypothalamus-pituitary-adrenal axis (HPA) activity. As gonadal steroids could be important modulators of HPA sex differences, stress responses were investigated in subjects of advanced age after dehydroepiandrosterone (DHEA) or placebo treatment. After a 2-week treatment with 50 mg DHEA daily or placebo, 75 men and women (mean age, 67.6 yr) were exposed to the Trier Social Stress Test (TSST). The TSST is a brief psychosocial stress that consists of a free speech and mental arithmetic task in front of an audience. The results show that the TSST induced significant increases in ACTH, salivary free cortisol, total plasma cortisol, norepinephrine, and heart rates (all P < 0.0001) as well as decreased positive affect in the elderly (P = 0.0009). Men showed larger stress responses in ACTH (P = 0.004), salivary free cortisol (P = 0.044), and plasma total cortisol (P = 0.076) compared to women. No sex differences were observed in norepinephrine, epinephrine, or heart rate responses. In contrast to ACTH and cortisol response differences, women reported that they were significantly more stressed by the TSST than men (P = 0.0051). Women treated with DHEA showed ACTH stress responses similar to those of men, but significantly enhanced compared to those of women taking placebos (P < 0.009). No other stress response differences emerged between DHEA and placebo groups. Finally, DHEA treatment did not result in an improvement of subjective well-being. We conclude that elderly men show larger HPA responses than women to psychosocial stress, as studied in the TSST. Estrogen effects on hypothalamic CRF-producing neurons might be responsible for these sex differences.</div>
</front>
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</country>
<region><li>Basse-Saxe</li>
<li>Hongrie centrale</li>
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   |texte=   Sex differences in endocrine and psychological responses to psychosocial stress in healthy elderly subjects and the impact of a 2-week dehydroepiandrosterone treatment
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Sex differences in endocrine and psychological responses to psychosocial stress in healthy elderly subjects and the impact of a 2-week dehydroepiandrosterone treatment

Sex differences in endocrine and psychological responses to psychosocial stress in healthy elderly subjects and the impact of a 2-week dehydroepiandrosterone treatment

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